To maintain homeostasis for survival, both rodents and primates have evolved to optimally orchestrate food intake in sensing ambient thermal challenges 9, 10, 11, 12, 13. Ambient temperature, as a pivotal homeostatic-related environmental factor, intimately orchestrate feeding behavior 5, 6, 7, 8. These findings reveal unrecognized cell populations and circuits of apMPOA that orchestrates feeding behavior against thermal challenges.įeeding behavior is regulated by multiple hard-wired neural circuits that underlie diverse internal homeostatic factors and external environmental factors 1, 2, 3, 4, 5. Further projection-specific RNA sequencing and fluorescence in situ hybridization identify that the two neuronal populations are molecularly marked by galanin receptor and apelin receptor.
Caspase ablation or chemogenetic inhibition of the apMPOA→PVH pathway can eliminate the temperature dependence of feeding. The other type, the paraventricular hypothalamic nucleus (PVH)-projecting neurons in apMPOA are primarily sensitive to high temperature and suppress food intake. While both populations are glutamatergic, the arcuate nucleus-projecting neurons in apMPOA can sense low temperature and promote food intake. Two neighboring but distinct neuronal populations in apMPOA mediate feeding behavior by receiving anatomical inputs from external and dorsal subnuclei of lateral parabrachial nucleus. Here we find that a non-canonical feeding center, the anteroventral and periventricular portions of medial preoptic area (apMPOA) respond to altered dietary states in mice. However, the mechanisms underlying temperature-coordinated feeding behavior are rarely reported. Both rodents and primates have evolved to orchestrate food intake to maintain thermal homeostasis in coping with ambient temperature challenges.
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